Cortical-spreading depression: at the razor’s edge of scientific logic
نویسندگان
چکیده
منابع مشابه
P 23: Apoptosis Following Cortical Spreading Depression in Juvenile Rats
Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...
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Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
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The brain is a complex organ with active components composed largely of neurons, glial cells, and blood vessels. There exists an enormous experimental and theoretical literature on the mechanisms involved in the functioning of the brain, but we still do not have a good understanding of how it works on a gross mechanistic level. In general, the brain maintains a homeostatic state with relatively...
متن کاملThe Neuroprotective Effects of Long-Term Repetitive Transcranial Magnetic Stimulation on the Cortical Spreading Depression-induced Damages in Rat’s Brain
Introduction: Cortical Spreading Depression (CSD) is a propagating wave of neural and glial cell depolarization with important role in several clinical disorders. Repetitive Transcranial Magnetic Stimulation (rTMS) is a potential tool with preventive treatment effects in psychiatric and neuronal disorders. In this paper, we study the effects of rTMS on CSD by using behavioral and histological a...
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Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 2-5 mm/min and is followed by a 5-10 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain surfaces. The usefulness of the technique is demonstrate...
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ژورنال
عنوان ژورنال: The Journal of Headache and Pain
سال: 2011
ISSN: 1129-2369,1129-2377
DOI: 10.1007/s10194-010-0287-z